Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

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Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

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Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

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Título: Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain
Autor: Faure-André, Gabrielle; Vargas, Pablo; Yuseff, Maria-Isabel; Heuzé, Mélina; Diaz, Jheimmy; Lankar, Danielle; Steri, Veronica; Manry, Jeremy; Hugues, Stéphanie; Vascotto, Fulvia; Boulanger, Jérôme; Raposo, Graça; Bono, María Rosa; Rosemblatt, Mario; Piel, Matthieu; Lennon Duménil, Ana María
Resumen: Dendritic cells ( DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II- associated invariant chain (li or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild- type DCs alternate between high and low motility, whereas li-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by li depended on the actin- based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.
URI: http://www.captura.uchile.cl/handle/2250/7098
Fecha: 2008-12-12
Cita del item: SCIENCE Volume: 322 Issue: 5908 Pages: 1705-1710 Published: DEC 12 2008


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