Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica

Abstract

Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important pharmacological targets. Aim: To evaluate genotype and gene-gene interaction between beta(1)-AR Arg389Gly and beta(2)-AR Arg16Gly, Gln27Glu and Thr1641le polymorphisms, as risk factors for HF, Material and methods: Eighty chronic HF patients and eighty-eight controls matched by age and sex were genotyped for beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly, Gln27Glu and Thr1641le polymorphisms. Results. The presence of beta(2)-AR Glu allele was a risk predictor for HF (odds ratio (OR) = 2.81; 95% confidence intervals (CI) = 1.49-5.31). Interactions that increased the risk for HF were found in patients carrying at least one of the beta(2)-AR Glu and beta(2)-AR Gly allele (OR = 3.81: 95% CI = 1.50-0.70) and beta(2)-AR Glu and beta(1)-AR Gly allele combination (OR = 5.51; 95% CI = 2.19-13.86). Furthermore, the frequency of beta(2)-AR Gly allele was higher among patients with a history of acute myocardial infarction (with infarction: 0.534, without: 0.313, p=0.01). Conclusions: beta(2)-AR Gly allele could be a risk predictor for HF. This risk could be enhanced by the additional presence of beta(2)-AR Gly16 or beta(1)-AR Arg389 alleles. The frequency of beta(2)-AR Gln27 Glu allele was higher among patients with a history of myocardial infarction.