La melatonina reduce la respuesta de cortisol al ACTH en humanos

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La melatonina reduce la respuesta de cortisol al ACTH en humanos

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La melatonina reduce la respuesta de cortisol al ACTH en humanos

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Título: La melatonina reduce la respuesta de cortisol al ACTH en humanos
Autor: Campino, Carmen; Valenzuela, Francisco; Arteaga, Eugenio; Torres Farfán, Claudia; Trucco, Cristián; Velasco, Alfredo; Guzmán, Sergio; Serón Ferré, María
Resumen: Background: Melatonin receptors are widely distributed in human tissues but they have not been reported in human adrenal gland. Aim: To assess if the human adrenal gland expresses melatonin receptors and if melatonin affects cortisol response to ACTH in dexamethasone suppressed volunteers. Material and methods: Adrenal glands were obtained from 4 patients undergoing unilateral nephrectomy-adrenalectomy for renal cancer. Expression of mRNA MT1 and MT2 melatonin receptors was measured by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). The effect of melatonin on the response to interavenous (i.v.) ACTH was tested (randomized cross-over, double-blind, placebo-controlled trial) in eight young healthy males pretreated with dexamethasone (1 mg) at 23:00 h. On the next day, at 08:00 h, an i.v. line was inserted, at 08:30 h, and after a blood sample, subjects ingested 6 mg melatonin or placebo. At 09:00 h, and after a blood sample, subjects surface area) was injected, drawing samples at 0, 15, 30, 45 and 60 minutes after. Melatonin, cortisol, cortisone, progesterone, aldosterone, DHEA-S, testosterone and prolactin were measured by immunoassay. Results: The four adrenal glands expressed only MT1 receptor mRNA. Melatonin ingestion reduced the cortisol response to ACTH from 14.6 +/- 1.45 mu g/dl at 60 min in the placebo group to 10.8 +/- 1.2 mu g/dl in the melatonin group (p<0.01 mixed model test). It did not affect other steroid hormone levels and abolished the morning physiological decline of prolactin. Conclusions: The expression of MT1 melatonin receptor in the human adrenal, and the melatonin reduction of ACTH-stimulated cortisol production suggest a direct melatonin action on the adrenal gland.
URI: http://www.captura.uchile.cl/handle/2250/6769
Fecha: 2008-11
Cita del item: REVISTA MEDICA DE CHILE Volume: 136 Issue: 11 Pages: 1390-1397 Published: NOV 2008


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