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Title:
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SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY |
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Author:
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Pessoa, H.; González Lira, Christian Guillermo; Araya Maturana, R.; Saitz B., C.; Pessoa, D.
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Abstract:
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New benzothiophene arylpiperazine derivatives 7 (a-1) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4,7-dimethoxy-1-benzothien-2-yl)carbonyl] piperazine (6) with a series of substituted aroyl chlorides. |
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URI:
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http://www.captura.uchile.cl/handle/2250/6529
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Date:
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2009-06 |
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dc.identifier.citation:
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JOURNAL OF THE CHILEAN CHEMICAL SOCIETY 54(2): 147-150 |