alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals

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alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals

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alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals

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Título: alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals
Autor: Donoso, M. V.; Carvajal, A.; Paredes, Alfonso; Tomic, A.; Koenig, Cecilia S.; Huidobro Toro, Juan Pablo
Resumen: Neuropeptide Y (NPY) and noradrenaline (NA) are co-transmitters at many sympathetic synapses, but it is not yet clear if their release is independently regulated. To address this question, we quantified the electrically evoked release of these co-transmitters from perivascular nerve terminals to the mesenteric circulation in control and drug-treated rats. 6-Hydroxydopamine reduced the tissue content and the electrically evoked release of ir-NPY and NA as well as the rise in perfusion pressure. A 0.001 mg/kg reserpine reduced the content of ir-NPY and NA, but did not modify their release nor altered the rise in perfusion pressure elicited by the electrical stimuli. However, 0.1 mg/kg reserpine reduced both the content and release of NA but decreased only the content but not the release of ir-NPY; the rise in perfusion pressure was halved. Clonidine did not affect the release of ir-NPY while it lowered the outflow of NA, not altering the rise in perfusion pressure elicited by the electrical stimuli. Yohimbine, did not modify the release of ir-NPY but increased the NA outflow, it antagonized the clonidine effect. Therefore, presynaptic alpha(2)-adrenoceptors modulate the release of NA but not NPY, implying separate regulatory mechanisms.
URI: http://www.captura.uchile.cl/handle/2250/6307
Fecha: 2002-09
Cita del item: PEPTIDES 23(9):1663-1671


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