CHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH

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CHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH

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Título: CHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH
Autor: Cordano, G.; Yung Engel, Carlos; Muñoz, S.; Marrese Cabezas, Juan Carlos; Muñoz de la Peña Bueno, Amalia; Medina, Jorge
Resumen: The incorporation of [1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole] (metronidazole), modified by treatment with succinic, glutaric and phtalic anhydrides on starch was studies. For the reaction the starch was previously activated with pyridine-water until gelification in the presence of dicyclohexylcarbodiimide (DCC) as a dehydrant agent and N,N,-dimethylaminopyridine (DAMP) as a catalyst. Incorporation of metronidazole on starch ranged up to 21.20%. Products were characterized by IR spectroscopy, and the incorporated drug determined by releasing the nitrate ion from the metronidazole followed by its quantification by a colorimetric technique.
URI: http://www.captura.uchile.cl/handle/2250/6044
Fecha: 1985-12
Cita del item: BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA 34(4):279-285


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