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Title:
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Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies |
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Author:
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Olea Azar, Claudio; Rigol, Carolina; Mendizábal, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto, Yolanda; Maya, Juan Diego
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Abstract:
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In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide
derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed.
Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction
processes. Effects on the parasitic respiration were studied. |
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URI:
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http://www.captura.uchile.cl/handle/2250/5928
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Date:
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2005-06 |
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dc.identifier.citation:
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LETTERS IN DRUG DESIGN & DISCOVERY V.: 2, issue: 4, p.: 294-301: JUN 2005 |