Synthesis of 2-aryl-1,3-propanediamines using a one-pot Knoevenagel-Michael sequence

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Synthesis of 2-aryl-1,3-propanediamines using a one-pot Knoevenagel-Michael sequence

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Synthesis of 2-aryl-1,3-propanediamines using a one-pot Knoevenagel-Michael sequence

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Title: Synthesis of 2-aryl-1,3-propanediamines using a one-pot Knoevenagel-Michael sequence
Author: Iturriaga Vásquez, Patricio; Lühr Sierra, Susan; Caroli Rezende, Marcos; Cassels, Bruce K.
Abstract: A simple synthetic route for the preparation of 2-phenyl-1,3-propanediamines, based on a Knoevenagel-Michael double condensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium bicarbonate as base in the first step, followed by catalytic hydrogenation over Adams catalyst.
URI: http://www.captura.uchile.cl/handle/2250/5774
Date: 2006-03
dc.identifier.citation: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY Volume: 51 Issue: 1 Pages: 781-783 Published: MAR 2006


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