Voltammetric study of nitro radical anion generated from some nitrofuran compounds of pharmacological significance

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Voltammetric study of nitro radical anion generated from some nitrofuran compounds of pharmacological significance

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Voltammetric study of nitro radical anion generated from some nitrofuran compounds of pharmacological significance

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Título: Voltammetric study of nitro radical anion generated from some nitrofuran compounds of pharmacological significance
Autor: Bollo Dragnic, Soledad; Núñez Vergara, Luis J.; Martínez, C.; Chauviere, G.; Perie, J.; Squella Serrano, Juan Arturo
Resumen: The electrochemical behavior of 2-(5-amino- 1,3,4-oxadiazolyl)-5-nitrofuran (NF359) and its comparison with well known drugs such as nifurtimox (NFX) and nitrofurazone (NFZ) in protic, mixed and aprotic media by cyclic voltammetry, tast and differential pulse polarography was studied. All the compounds were electrochemically reducible in all media being the reduction of the nitrofuran group. the main voltammetric signal. The one-electron reduction couple due to the nitro radical anion formation was visualized in mixed (for NF359 and NFZ) and aprotic media (for all compounds). By applying a cyclic voltammetric methodology we have calculated the decay constants (k(2)) of the corresponding nitro radical anions in mixed and aprotic media. In mixed medium data fit well with a disproportionation reaction of the nitro radical anion but in aprotic medium, fit better with a dimerization reaction. Also, considering cyclic voltammetric measurements in aprotic media we have estimated the reduction potential of the RNO2/RNO2- couple in aqueous medium, pH 7 (E-7(1) values) finding very good correlation with E-7(1) values obtained by pulse radiolysis. Furthermore we have calculated the equilibrium constants from the electron transfer from nitro radical anion to oxygen (k(O2)) finding that nitro radical anion from NF359 is thermodynamically favored to react with oxygen in respect to both NFZ and NFX.
URI: http://www.captura.uchile.cl/handle/2250/5157
Fecha: 2003-01
Cita del item: ELECTROANALYSIS 15(1):19-25


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