Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide

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Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide

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Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide

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Título: Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide
Autor: Ortíz Yáñez, María Eugenia; Núñez Vergara, Luis J.; Camargo, C.; Squella, J. A.
Resumen: The final pyridine derivatives were separated and identified by gas chromatography/ mass spectrometry (GC-MS). The intermediates, anion dihydropyridine and the HO2./HO2- species, were observed from voltammetric studies and controlled potential electrolysis was used to electrogenerate O-2(radial anion). Results. The current work reveals that electrogenerated superoxide can quantitatively oxidize Hantzsch dihydropyridines to produce the corresponding aromatized pyridine derivatives. Conclusions. Our results indicate that the aromatization of Hantzsch dihydropyridines by superoxide is initiated by proton transfer from the N1-position on the 1,4-dihydropyridine ring to give the corresponding anion dihydropyridine, which readily undergoes further homogeneous oxidations to provide the final aromatized products. The oxidation of the anionic species of the dihydropyridine is more easily oxidized than the parent compound.
URI: http://www.captura.uchile.cl/handle/2250/5140
Fecha: 2004-03
Cita del item: PHARMACEUTICAL RESEARCH 21(3):428-435


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