Electrochemical study of 4-substituted analogues of megazol

Abstract

The electrochemical behavior of three different megazol analogues substituted at position 4 and their comparison with the parent compound megazol in protic and aprotic media by cyclic voltarnmetry, Tast and differential pulse polarography was studied. All the compounds were electrochemically reducible in both media with the reduction of the nitroirnidazole group the main voltarnmetric signal. The one-electron reduction couple due to the nitro radical anion formation was visualized only in aprotic media for all these compounds. By applying cyclic voltarnmetric methodology we have calculated the dimerization reaction decay constants (k(2)) of the corresponding nitro radical anions in aprotic media. The nitro radical anion obtained from the synthesized nitroirnidazole compound having a bromine substituent in 4-position (GC-141) was significantly more stable than the corresponding radical formed from the compound lacking of the substituent in 4-position, megazol.