Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis

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Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis

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Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis

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Título: Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis
Autor: Santibáñez, Juan Francisco; Hurtado, Claudia
Resumen: Efforts have been made to develop a chemoprevention that selectively triggers apoptosis in malignant cancer cells. Here, we demonstrated that a mutated Ha-Ras activity is required in Anisomycin-induced apoptosis in transformed keratinocytes. Anisomycin stimulates JNK activity and apoptosis in oncogenic Ha-Ras positive cells, but not in normal keratinocytes. This effect was demonstrated in stably transfected cells with dominant negative Ha-Ras, that protected transformed cells, and oncogenic Ha-Ras that sensitized non-transformed cells to Anisomycin-induced apoptosis. Lastly, the treatment of cells with inhibitors of the JNK displayed resistance to Anisomycin induced apoptosis. These data suggests that the oncogenic Ha-Ras is important for Anisomycin-induced JNK activation and apoptosis in transformed keratinocvtes. 2005 Federation of European Biochemical Societies.
URI: http://www.captura.uchile.cl/handle/2250/2363
Fecha: 2005-11-21
Cita del item: FEBS LETTERS


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