Oxidative stress in pericardial fluid and plasma and its association with ventricular function

Abstract

There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress markers in pericardial fluid and plasma are associated with left ventricular function. Methods and results: Twenty-eight consecutive patients (class I or II NYHA) scheduled for myocardial revascularization, valve replacement, valve repair or closure of atrial septal defect. Plasma and pericardial fluid were collected and malondialdehyde, catalase, superoxide dismutase and glutathione peroxidase were determined. Left ventricular ejection fraction, left ventricular end diastolic diameter and left ventricular end systolic diameter were determined as echocardiographic indexes of ventricular function.

We found that oxidative stress determined by a simple malondialdehyde (NIDA) assay, correlated in plasma and pericardial fluid, and this parameter was associated with left ventricular end systolic diameter. Conclusion: Plasma and pericardial fluid malondialdehyde levels can be used as an early marker of ventricular dysfunction.