PRELlMINARY VOLTAMMETRIC DATA FOR THE OXIDATION OF 4-METHYLAMINOPHENETHYLAMINE DERIVATIVES IN BUFFER AND IN APROTIC SOLVENTS

Abstract

The electrochemistry 01 a series 01 monoamine oxidase-inhibitory 4-Nmethyl and N,N-dimethylaminophenethylamines was studied using cyclic voltammetry. Electron transler was irreversible both in aqueous buffer.(pH = 7.4) and in aprotic solvents. The peak potentials in buffer solution Hebetween 0.59 and 0.63 V, and increase only slightly upon addition 01 up to 20% (vlv) acetonitrile. These potentials are low enough lor these phenethylamine derivatives to be detected electrochemically under standard conditions used lor HPLC analysis 01 catecholamines, serotonin, and their metabolites.