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Title:
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6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids |
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Author:
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Marder, Mariel; Viola, Haydee; Wasowski, Cristina; Wolfman, Claudia; Waterman, Peter G.; Cassels, Bruce K.; Medina, Jorge H.; Paladini, Alejandro C.
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Abstract:
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6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors witb a
Ki =70 nM and has a clear anxiolytic activity in mice, at 0.5 mgJkg, i.p. A survey of tbe structure/affinity relationship
for tbose receptors in a series of natural and syntbetic flavonoids is presented. |
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URI:
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http://www.captura.uchile.cl/handle/2250/16901
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Date:
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1996-04-13 |
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dc.identifier.citation:
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 223, p. 384-389, Article nº 0903, 1996. |