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Title:
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SINTESIS DE 1-ARIL-2-NITROALQUENOS ANTITUMORALES |
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Author:
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Cassels, Bruce K.; Herreros, S.; Ibáñez, C.; Rozende, M. C.; Sebastían, C.; Sepúlveda, S.
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Abstract:
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l-Aryl-2-nitroalkenes can. ba synthesized mest convéniently by refluxing
aromatic aidehydes with nitromethane 01' nitroethane in acetic acid using n-butyla
llIineas a catalyst •.{ In this way' seventeen nev cOIIl'PC'lmdosf this type aad seve-raI
known ana10gues withalkaxy andhalo ring substituents ware prepared. without the
CODcurrent production ol the corref5l'011dingly' substituted benzonitrii_. Moat of
thes!! compounds were- tested in theP-J88 murine 1ympbocytic leuk.emia aseay; {QUr
of them pc~s_sed reproducible antitumor activity, and another five gav& si~ficantiy
increased survival times wtri.ch _re not rept'Oduced |
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URI:
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http://www.captura.uchile.cl/handle/2250/16884
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Date:
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1981-12 |
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dc.identifier.citation:
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Anales Asoc. Quím. Argentina , 70, 283-288, 1982. |