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Title:
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Microbial Transformation of Marine Halogenated Sesquiterpenes |
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Author:
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San Martin, Aurelio; Rovirosa, Juana; Carrasco, Alvaro; Orejarena, Silvia; Soto-Delgado, Jorge; Contreras, Renato; Chamy, M. Cristina
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Abstract:
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The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the
semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to
obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus
níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological
transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new
compounds obtained were determined by spectroscopic means. |
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URI:
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http://www.captura.uchile.cl/handle/2250/16639
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Date:
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2010-11-12 |
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dc.identifier.citation:
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Natural Product Communications, Vol. 5, No. 12: 1859 - 1864, 2010. |