|
Title:
|
A two-step method for the preparation of homochiral cathinones |
|
Author:
|
Osorio Olivares, Mauricio; Caroli Rezende, Marcos; Sepúlveda Boza, Silvia; Cassels, Bruce K.; Baggio, Ricardo F.; Muñoz Acevedo, Juan C.
|
|
Abstract:
|
Abstract—A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 (‘cathinones’) is
described, involving initial Friedel–Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by
acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the
structures. |
|
URI:
|
http://www.captura.uchile.cl/handle/2250/16626
|
|
Date:
|
2003-03-12 |
|
dc.identifier.citation:
|
Tetrahedron: Asymmetry Vol. 14, p. 1473–1477, 2003. |