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Title:
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Effects of 4,4-Dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-Dimethyl-5,8-dihydroxytetralone Derivatives onTumor Cell Respiration |
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Author:
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Araya Maturana, Ramiro; Delgado Castro, Tomás; Gárate, Mario; Ferreira, Jorge; Pavani, Mario; Pessoa Mahana, Hernán; Cassels, Bruce K.
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Abstract:
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Abstract—A set of structurally related compounds incorporating a carbonyl group in the ortho position withregard to a phenol
function were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. The series consists
of 20-hydroxyacetophenone, 40-hydroxyacetophenone 20,50-dihydroxyacetophenone, 4-acetyl-3,3-dimethyl-5-hydroxy-2-morpholino-
2,3-dihydrobenzobfuran, five 4,4-dimethyl-5,8-dioxygenated naphtalene-1-ones and three 4,4-dimethyl-5,8-dioxygenated tetralones.
A tentative structure–activity relationship was found for this family of substances, suggesting that a coplanar ortho-carbonyl-
1,4-hydroquinone motif is able to cause inhibition of cellular respiration. |
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URI:
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http://www.captura.uchile.cl/handle/2250/16459
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Date:
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2002-01-29 |
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dc.identifier.citation:
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Bioorganic & Medicinal Chemistry, 10: 3057–3060, 2002. |