The Revitalized Tau Hypothesison Alzheimer's Disease

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The Revitalized Tau Hypothesison Alzheimer's Disease

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Título: The Revitalized Tau Hypothesison Alzheimer's Disease
Autor: Maccioni, Ricardo B.; Farías, Gonzalo; Morales, Inelia; Navarrete, Leonardo
Resumen: Many hypotheseshavebeenraisedregardingthepathophysiologyofAlzheimer’sdisease (AD).Becauseamyloidbetapeptide(Ab) depositioninsenileplaquesappearsasalate, nonspecificevent,recentevidencepointstotauphosphorylationandaggregationasthe finalcommonpathwayinthismultifactorialdisease.Currentapproachesthatprovide evidenceinfavorofneuroimmunomodulationinADandtherolesoftaupathological modificationsandaggregationintooligomersandfilamentousformsarepresented.We proposeanintegrativemodelonthepathogenesisofADthatincludesseveraldamage signalssuchasAb oligomers,oxygenfreeradicals,ironoverload,homocysteine, cholesterolandLDLspecies.Theseactivatemicrogliacells,releasingproinflammatory cytokines andproducingneuronaldegenerationandtaupathologicalmodifications. Alteredandaggregatedformsoftauappeartoactasatoxicstimulicontributingto neurodegeneration.Recentfindingsprovidefurthersupporttothecentralroleoftauin the pathogenesisofAD,sothisproteinhasturnedintoadiagnosticandtherapeutictarget for thisdisease.
URI: http://www.captura.uchile.cl/handle/2250/14708
Fecha: 2010-03-01
Cita del item: Archives of Medical Research, 41, 226-231, 2010.


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