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Title:
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Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids |
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Author:
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Molina Salinas, Gloria María; Bórquez, Jorge; Ardiles, Alejandro; Said Fernández, Salvador; Loyola, Luis Alberto; Yam Puc, Alejandro; Becerril Montes, Pola; Escalante Erosa, Fabiola; San Martín, Aurelio; González Collado, Isidro; Peña Rodríguez, Luis Manuel
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Abstract:
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Natural products are recognized as an
important source of new and better pharmaceuticals
for the treatment of diseases such as tuberculosis. The
azorellane and mulinane diterpenoids represent an
interesting group of bioactive metabolites produced
by Andean plants belonging to the Azorella, Mulinum,
Laretia and Bolax genus. Testing of natural and
semisynthetic azorellanes and mulinanes against two
Mycobacterium tuberculosis strains showed that
while most changes in the structure of the natural
metabolites result in the loss of antituberculosis
activity, methylation of the C-20 carboxyl group
improves the biological activity of the corresponding
derivatives. |
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Description:
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Artículo de publicación ISI. |
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URI:
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http://www.captura.uchile.cl/handle/2250/14548
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Date:
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2010-02-17 |
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dc.identifier.citation:
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PHYTOCHEMISTRY REVIEWS, Volume: 9, Issue: 2, Special Issue: SI, Pages: 271-278, 2010 |