Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia

Manakin: DSpace XMLUI Project v2

Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia

Cómo citar
Cómo citar

Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia

.
Copiar
Título: Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia
Autor: Galleguillos, M.; Valenzuela, M. A.; Riquelme, Raquel; Sanhueza, E.M.; Sánchez, G.; Figueroa, J. P.; Llanos, A. J.
Resumen: The fetal llama (Lama glama; a species adapted to live in chronic hypoxia in the highlands of the Andes) did not increase cerebral blood flow and reduce the brain oxygen uptake during hypoxemia. Although nitric oxide (NO) is a normal mediator in the regulation of vascular tone and synaptic transmission, NO overproduction by hypoxemia could produce neuronal damage. We hypothesized that nitric oxide synthase (NOS) activity is either maintained or reduced in the central nervous system of the llama fetuses submitted to chronic hypoxemia. Approximately 85% of the Ca2+-dependent NOS activity was soluble, at least 12% was associated with the mitochondrial fraction, and less than 5% remains associated with microsomes. To understand the role of NO in chronic hypoxemia, we determined the effect of 24-h hypoxemia on NOS activity in the central nervous system. No changes in activity or the subcellular distribution of NOS activity in brain tissues after hypoxemia were found. We proposed that the lack of changes in NOS activity in the llama under hypoxemia could be a cytoprotective mechanism inherent to the llama, against possible toxic effects of NO.
Descripción: Artículo de publicación ISI
URI: http://www.captura.uchile.cl/handle/2250/14246
Fecha: 2001-06
Cita del item: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 129 (2-3): 605-614


Archivos vinculados

Formato: Nombre: Tamaño: Descripción: Ver
PDF
GALLEGUILLOS_2001.pdf
9.207Mb
Abrir / Descargar

El ítem tiene asociados los siguientes archivos de licencia:

Este ítem aparece en la(s) siguiente(s) colección(ones)