A convenient, renewable source of the anxiolytic proaporphine alkaloid glaziovine: Duguetia vallicola leaves

Abstract

The leaves of Duguetia vallicola, a fairly common, large evergreen tree from the coastal regions of Panama, Colombia and Venezuela, contain (6aS)-glaziovine (1) as a major constituent. The abundance and renewable character of the plant material make it an attractive source for this rare, psychoactive alkaloid. The availability of glaziovine and its 0-methyl derivative pronuciferine (2) has made complete H-1 and C-13 NMR assignments of proaporphines possible for the first time.