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Title:
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Synthesis of a Novel Series of 4-Arylpiperazinyl Derivatives Linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as New Delavirdine Analogues |
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Author:
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Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime; Pessoa Mahana, Hernán
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Abstract:
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The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-benzimidazole derivatives are structurally related to the anti-HIV-1 drug Delavirdine and belong to the bis(heteroaryl)piperazines family (BHAPs), a well known HIV-1 reverse transcriptase inhibitors group. |
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URI:
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http://www.captura.uchile.cl/handle/2250/11193
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Date:
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2010 |
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dc.identifier.citation:
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J. Braz. Chem. Soc., Vol. 21, No. 1, 63-70, 2010. |