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Title:
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Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity |
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Author:
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Pessoa, H.; Acevedo Ramos, Armando Rodrigo; Araya Maturana, R.; Saitz B., C.; Pessoa, D.
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Abstract:
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New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl]-4,7-dimethoxybenzo[b]thiophene-2-carboxamide (7) with a series of substituted 4-arylpiperazines. |
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URI:
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http://www.captura.uchile.cl/handle/2250/10792
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Date:
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2007 |
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dc.identifier.citation:
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SYNTHETIC COMMUNICATIONS 37(19-21): 3559-3567 |