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Title:
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Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action |
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Author:
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Pessoa, H.; Recabarren Gajardo, Gonzalo Iván; Araya Maturana, R.; Kosche Cárcamo, Johann Albert; Pessoa, D.
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Abstract:
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We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual pharmacological profile: MAO-A inhibitor and 5-HT1A receptor affinity. |
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URI:
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http://www.captura.uchile.cl/handle/2250/10791
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Date:
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2004-07 |
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dc.identifier.citation:
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SYNTHETIC COMMUNICATIONS 34(14): 2513-2521 |