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Title:
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Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones |
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Author:
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Otero, Lucía; Maya, Juan Diego; Morello, A.; Rigol, C.; Barriga, Germán; Rodríguez, J.; Folch, C.; Norambuena, Ester; González, M.; Olea Azar, Claudio; Cerecetto, Hugo; Gambino, D.
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Abstract:
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In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones
some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated
in T. cruzi by compounds´ bioreduction were analyzed. Three different patterns of ESR signals were observed for the
different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted
by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity
(ORAC), did not seem to correlate with the trypanocidal activity. |
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URI:
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http://www.captura.uchile.cl/handle/2250/10335
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Date:
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2008 |
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dc.identifier.citation:
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Medicinal Chemistry, 2008, 4, 11-17 |