Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. Estrés oxidativo e inflamación en insuficiencia cardíaca. Mecanismos de daño y alternativas terapéuticas.

Abstract

Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a higber generation Qf reactive ox en species, This phenoinenon, along wilb pro-n flamnzatory cytokine activation.Y9 and extra cellular matrix alterations with reactivefibrosis, play all important role in the pathogenesis andprogression oj'beartftiilure, through the development of endothelial and inyocardial dY-01inction. 7he understanding qf the under yingj phenomena and the metabolic pathways involved will allow further development ql'therapies ainling to chanqe The natural bisloiy of beartft7ilure