Browsing by Subject "SYNAPTIC PLASTICITY"

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Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca(2+) Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

Paula-Lima, Andrea C.;Adasme, Tatiana;San Martín, Carol;Sebollela, Adriano;Hetz, Claudio;Carrasco, M. Angélica;Ferreira, Sergio T.;Hidalgo, Cecilia (2011-04)

Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A bet....
Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes

Sandoval, Mauricio;Sandoval, Rodrigo;Thomas, Ulrich;Spilker, Christina;Smalla, Karl-Heinz;Falcón, Romina;Marengo, Juan José;Calderón, Rodrigo;Saavedra, Verónica;Heumann, Rolf;Bronfman, Francisca;Garner, Craig C.;Gundelfinger, Eckart D.;Wyneken, Ursula (2007)

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are essential regulators of synaptic function in the adult CNS. A TrkB-mediated effect at excitatory synapses is enhancement of NMDA receptor (NMDA....
Calcium, iron and neuronal function

Hidalgo, Cecilia;Núñez, Marco T. (2007)

Calcium and iron play dual roles in neuronal function: they are both essential but when present in excess they cause neuronal damage and may even induce neuronal death. Calcium signals are required for synaptic....
Calcium microdomains and gene expression in neurons and skeletal muscle cells

Carrasco, María Angélica;Hidalgo, Cecilia (2006-12)

Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in....
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons

Kemmerling, Ulrike;Muñoz, Pablo;Müller, Marioly;Sánchez, Gina;Aylwin, María L.;Klann, Eric;Carrasco, María Angélica;Hidalgo, Cecilia (2007)

Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox mod....
Melatonin administration impairs visuo-spatial performance and inhibits neocortical long-term potentiation in rats

Soto Moyano, Rubén;Burgos, Héctor;Flores, Francisco;Valladares, Luis;Sierralta, Walter;Fernández, Víctor;Pérez, Hernán;Hernández, Paula;Hernández, Alejandro (2006-10)

Melatonin has been shown to inhibit long-term potentiation (LTP) in hippocampal slices of rats. Since LTP may be one of the main mechanisms by which memory traces are encoded and stored in the central nervous s....

Now showing items 1-6 of 6

Browsing by Subject "SYNAPTIC PLASTICITY"

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Browsing by Subject "SYNAPTIC PLASTICITY"

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